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KMID : 1100720120320010095
Annals of Laboratory Medicine
2012 Volume.32 No. 1 p.95 ~ p.98
CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
Seok Yoon-Mi

Kim Ju-Won
Choi Jong-Rak
Kim Yu-Ri
Park Seo-Jin
Kim Sue-Jung
Song Jae-Woo
Lee Kyung-A
Abstract
The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
KEYWORD
Mantle cell lymphoma, CCND1, MYC
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